Aiming at the scarcity of large-pixel large-area array detector chips used in star sensors, a design scheme of an imaging module based on domestic high-sensitivity CMOS image sensors (CIS) is proposed. According to the working principle of the star-sensitive imaging module, the hardware circuit of the star-sensitive imaging module based on CIS is designed. An interactive high-speed data transmission mode of FPGA software and DSP software based on the AEI (Advanced Extensible Interface) bus control module is developed. Moreover,technical parameters such as non-uniformity, linearity, dynamic range, and signal-to-noise ratio, which are concerned in the practical application of star sensors, are tested. The results show that these indicators of the CIS star-sensitive imaging module meet the actual application requirements for star detection.