A multiplex interface circuit for high frame rate CMOS image sensor(CIS) is presented. Supporting transmit datas in 2 , 4,8 or1 6 channels, Multi-channel parallel output of CIS image sensor signal is reliazed , and the signal read out sequence can also be controlled. The circuit has been validated to have the whole function with simulation and fabricated in CSMC 0.11um CMOS technology. It has been used in one high frame rate CMOS image sensor. This circuit improves the data transmission rate, extremely effective in the use of large scale of CIS arrays, and it’s controllability of read out sequence satisfies many demands.